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To increase alertness and wakefulness, modafinil Modalert 200 mainly acts on brain neurotransmitters including dopamine, norepinephrine, and histamine. While its primary mechanism of action is in the CNS, modafinil may indirectly affect hormone levels, according to some studies. The stress hormone cortisol may be one of the hormones that modafinil influences, according to some research. Elevated cortisol levels, especially in reaction to stressful events, have been linked to modafinil use. Modafinil may also affect other hormones that control hunger, mood, and the sleep-wake cycle.